Remielinización y Vitamina D
We observed that cholecalciferol is more efficient than ergocalciferol
and, when delivered at a high dose (500 IU/kg/day), cholecalciferol
induces a significant locomotor and electrophysiological recovery. We
also demonstrated that cholecalciferol increases i) the number of
preserved or newly formed axons in the proximal end, ii) the mean axon
diameter in the distal end, and iii) neurite myelination in both distal
and proximal ends. Finally, we found a modified expression of several
genes involved in axogenesis and myelination, after 24 hours of vitamin
supplementation. Our study is the first to demonstrate that vitamin D
acts on myelination via the activation of several myelin-associated
genes. It paves the way for future randomised controlled clinical trials
for peripheral nerve or spinal cord repair.
La disminución de vitamina D circulante provocada por el hígado atacado por la hemocromatosis, podría ser la causa de la neuropatía.
Probaremos si esto mejora administrando Vitamina D.
La disminución de vitamina D circulante provocada por el hígado atacado por la hemocromatosis, podría ser la causa de la neuropatía.
Probaremos si esto mejora administrando Vitamina D.
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